Schmitt Lab

Publications

View Danielle’s ORCID Profile, NCBI Bibliography, or Google Scholar

Danielle Schmitt Lab
Find and request materials through
Addgene

*As corresponding author

  1. Scully, J.M, Sun, M.J., Das, S., Arias, N.J., Kapelczak, E.D., Robinson, T.D., Vineall, K.G., Dean, T.S., TeSlaa, T., Divakaruni, A.S., Schmitt, D.L.* Illuminating spatial dynamics of glutamine metabolism with a sensitive genetically encoded biosensor. RSC Chemical Biology. 2026. 
  2. Cohen, K.A., Jhawar, A., Garcia, G., Goni, N., Chen, M., Alcala, A., Dean, T.S., Kapelczak, E.D., TeSlaa, T., Higuchi-Sanabria, R., and Schmitt, D.L.* Revealing the spatiotemporal dynamics of methionine metabolism with a genetically encoded single-fluorophore biosensor. BioRxiv, 2026 DOI: 10.64898/2026.06.05.730515
  3. Vineall, K.G. and Schmitt, D.L.* Measuring PINK1 Activity in Single Cells Using a PINK1 Kinase Activity Reporter. Bio-Protocol. 2026
  4. Jhawar, A., Parks, K., and Schmitt, D.L.*, Illuminating Compartmentalized AMPK Signaling. Biochemical Journal. 483 (6): 849–860, 2026 (review)
  5. Lee, R., Yeung, J., Mumford, T., Bugaj, L. Daniels M.J., Stanley, J., Pourmand, N., Vineall, Katie G., Schmitt, D.L., Rahman, S.M.T., and Sung, M-H. Non-invasive methods to monitor dynamic events in single cells. Trends in Cell Biology 2026. (review) PMC13089305
  6. Vineall K.G., Andrikopoulos A., Sun M.J., Yan A., Hartanto E.R., and Schmitt D.L.* Visualizing PINK1 Activity Dynamics in Single Cells with a Phase Separation-Based Kinase Activity Reporter. ACS Sensors, 2026
  7. Parks, K., Jhawar, A., Andrikopoulos, A., Winters, D.M., Dean, T.S., Kapelczak, E.D., TeSlaa, T., Bouhaddou, M., and Schmitt, D.L.*, Spatial regulation of AMPK activity under oxidative stress requires LKB1. BioRxiv, 2025 DOI: 10.1101/2025.11.17.688926.
  8. Brennan, P.J., Saunders, R.E., Spanou, M., Singleton, S.E., Serafini, M., Sun, L., Heger, G.P., Konopacka, A., Beveridge, R.D., Taylor, C.C., DePaola IV, P., Gordon, L., Bunally, S.B., Saudemont, A., Benowitx, A.B., Mertinez-Fleites, C., Schmitt, D.L., Damoiseaux, R., Queisser, M.A., An, H., Deane, C.M., Hann, M.M., Brayshaw, L.L., and Conway, S.J. Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells. ACS Chemical Biology, 2025.
  9. Ranzau, B.L.#, Robinson, T.D.#, Scully, J.M., Kapelczack, E.D., Dean, T.S., TeSla, T., and Schmitt, D.L.*A Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA. ACS Bio and Med Chem Au, 2024. #These authors contributed equally
    • Published as part of ACS Bio & Med Chem Au special issue “2024 Rising Stars in Biological, Medicinal, and
      Pharmaceutical Chemistry”
  10. Schmitt, D.L.* Imaging Subcellular AMPK Activity Using an Excitation-Ratiometric AMPK Activity Reporter. Current Protocols, 3, e771, 2023 
  11. Liu, L., Wang, Y., and Schmitt, Danielle L.* LUNAS: a rapid and sensitive nucleic acid detection assay using split NanoLuc luciferase complementation. ACS Central Science, “First Reaction”, 2023. 9, 593-596, 2023 (invited commentary)

Prior to UCLA

  1. Jeon, M. Schmitt, D.L., Kyoung, M., and An, S. Size-Specific Modulation of a Multienzyme Glucosome Assembly During the Cell Cycle. ACS Bio and Med Chem Au, 2023
  2. Schmitt, D.L., Dranchak, P., Parajuli, P., Blivis, D., Voss, T., Kohnhorst, C.L., Kyoung, M., Inglese, J., and An, S., High-throughput screening identifies cell cycle-associated signaling cascade that regulate a multienzyme glucosome assembly in human cells. PLOS ONE, 18(8), e0289707, 2023 
  3. Sahan, A.Z., Youngblood, E., Das, S., Schmitt, D.L., and Zhang, J. An expanded palette of ATP sensors for subcellular and multiplexed imaging. BioRxiv, 2023
  4. Peng, Q., Huang, Z., Sun, K., Yoon, C.W., Harrison, R.E.S., Schmitt, D.L., Zhu, L., Wu, Y., Tasan, I., Zhao, H., Zhang, J., Zhong, S., Chien, S., and Wang, Y. Engineering Inducible Biomolecular Assemblies for Genome Imaging and Manipulation in Living Cells. Nature Communications, 13, 7933, 2022
  5. Schmitt, D.L., Mehta, S., and Zhang, J. Study of spatiotemporal regulation of kinase signaling using genetically encodable molecular tools. Current Opinions in Chemical Biology, 71, 102224, 2022 (review)
  6. Schmitt, D.L., Curtis, S.D., Lyons, A.C., Chen, M., He, C.Y., Mehta, S., Shaw, R.J., and Zhang, J. Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter. Nature Communications, 13, 2022
  7. Schmitt, D.L., Mehta, S., Zhang, J. Illuminating the kinome: visualizing real-time kinase activity in biological systems using genetically encoded fluorescent protein-based biosensors. Current Opinion in Chemical Biology, 54, 63-69, 2020 (review)
  8. Ohadi, D., Schmitt, D.L., Calabrese, B., Halpain, S., Zhang, J., and Rangamani, P. Computational modeling reveals frequency modulation of calcium-cAMP/PKA pathway in dendritic spines, Biophysical Journal, 117, 1963-1980, 2019
  9. Schmitt, D.L., Sundaram, A., Jeon, M., Luu, B.T., and An, S. Spatial regulation of de novo purine biosynthesis by Akt-independent PDK1 signaling pathways, PLOS ONE, 13, e0195989, 2018
  10. Schmitt, D.L., An, S. Spatial Organization of Metabolic Enzyme Complexes in Cells, Biochemistry, 56, 3184 3196, 2017 (review)
  11. Kohnhorst, C. L., Kyoung, M., Jeon, M., Schmitt, D. L., Kennedy, E. L., Ramirez, J., Bracey, S. M., Luu, B.T., Russell, S. J., and An, S. Identification of a Multienzyme Complex for Glucose Metabolism in Living Cells, Journal of Biological Chemistry, 292, 9191-9203, 2017
  12. Schmitt, D. L., Cheng, Y., Park, J., and An, S. Sequestration-mediated downregulation of de novo purine biosynthesis by AMPK, ACS Chemical Biology, 11, 1917-24, 2016
  13. Kohnhorst, C. L., Schmitt, D.L., Sundaram, A., and An, S. Subcellular functions of proteins under fluorescence single-cell microscopy, BBA Proteins and Proteomics, 1864, 77-84, 2015 (review)
  14. Klee, T., Masterson, T., Miller, B., Barrasso, E., Ball, J., Lepkowiz, R., West, J., Haley, J. E., Schmitt, D. L., Flikkema, J. L., Cooper, T. M., Ruiz-Morales, Y., and Mullens, O. C. Triplet Electronic Spin States of Crude Oils and Asphaltenes, Energy and Fuels, 25, 2065-75, 2011

Patents

  1. An, S., Schmitt, D.L., Inglese, J., and Dranchak, P. Method of identifying a compound which affects the multienzyme metabolic assembly of glucose metabolism and its association with cell cycle progression in cancer cells. US Patent 11,474,097